%0 Journal Article
%T <i>In Vitro</i> Anticancer Assessment of <i>Annickia chlorantha</i> (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo
%A Damien S. Tshibangu
%A Selvaraj Divakar
%A Muthiah Ramanathan
%A Govindarajan Syamala
%A Koto-te-Nyiwa Ngbolua
%A Jean Chrysostome V. Mudogo
%A Dinangayi D. Tshilanda
%A Nicole M. Misengabu
%A Pius T. Mpiana
%J Journal of Biosciences and Medicines
%P 23-29
%@ 2327-509X
%D 2016
%I Scientific Research Publishing
%R 10.4236/jbm.2016.44004
%X In
this study, we evaluated the anti-cancer property of five bark extracts and the
isolates from chloroform and ethyl acetate of <i>Annickia chlorantha</i> by the tetrazolium salt method (MTT method).
The anti-cancer activity was performed on human prostate cancer cell lines PC-3
and hormone-dependent breast cancer cell lines MCF-7. Results indicated that
the two isolates displayed interesting cytotoxicity towards MCF-7 cell lines
with CC<sub>50</sub> of 3.84 CC<sub>50</sub>/mL and 4.87 CC<sub>50</sub>/mL for
chloroform and ethyl acetate respectively; while the total bark extracts showed
CC<sub>50</sub> of 24.33 CC<sub>50</sub>/mL, 36.49 CC<sub>50</sub>/ mL and
73.52 CC<sub>50</sub>/mL for chloroform, ethyl
acetate and methanol extracts respectively. By the other hand on PC-3, the CC<sub>50</sub> of the isolates were higher than the one on MCF-7, more than 10 CC<sub>50</sub>/mL
for both chloroform and ethyl acetate isolates and 49.14 CC<sub>50</sub>/mL,
77.33 CC<sub>50</sub>/mL, 89.38 CC<sub>50</sub>/mL and 92.37 CC<sub>50</sub>/mL,
respectively for chloroform, ethyl acetate and methanol soluble extracts. From
this study, we identified that the two isolates had anti-cancer properties
against MCF-7 cell lines.
%K &lt
%K i&gt
%K Annickia chlorantha&lt
%K /i&gt
%K Cancer
%K MCF-7 Cell Lines
%K PC-3 Cell Lines
%K Anti-Proliferative Compounds
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=65364