|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
nicotineinducedhepatotoxicityanditspreventionwithdatepalmpitpowder
DOI: 10.3724/SP.J.1145.2014.09005, PP. 489-493
Keywords: nicotine,hepatotxicity,datepalmpitpowder
Abstract:
cigarettesmokingiscommoninsocietiesworldwideandhasbeenidentifiedasinjurioustohumanhealth.nicotineisthemostabundantcomponentinthecigarettesmoke.itisfirstmetabolizedintheliver.thenaturaldietcontainsavarietyofcompounds,suchasdatepalm(phoenixdactyliferal.).itexhibitsprotectiveeffectagainstdifferenttoxins.theaimsofpresentstudyweretoinvestigatethedamagingeffectsofnicotineontheliverandthepreventiveroleofdatepalmagainstsuchdamage.datepalmpitpowderwasusedtostudyitsprotectiveeffectonnicotineinducedhepatotoxicity.threegroupsofadultmalealbinomicewereused,eachcontainingeightanimals.groupaservedasacontrol;groupbwasusedasanexperimentalgrouptreatedwithnicotine(0.3mg/kg)intraperitoneallyforforty-fivedays;groupcreceivednicotine(0.3mg/kg)intraperitoneallyalongwithdatepalmpitpowder(500mg/kg)orallyforforty-fivedays.histopathologicalexaminationrevealedthatthegeneralarchitecturewasdamagedwithincreaseinsizeofhepatocytes,centralveinandnumberoffatvacuolesandperiportalinfiltrationoflymphocytes.thenicotinetreatedmiceshoweddecreasedlevelofcytoplasmicvacuolization,necrosisandinflammation.datepalmpitpowderadministrationtonicotine-treatedmiceshowedreversionofthedamagedfeaturetonearlynormal.theseresultsalongwithpreviousstudysuggestthatdatepalmpitpowderisusefulincombatingnicotineinducedhepatotoxicity.
| [1] | 8hukkanenj,jacobp,benowitznl.metabolismanddispositionkineticsofnicotine[j].pharmacolrev,2005,57(1):79-115
|
| [2] | 10kavitharajnk,vijayammalpl.nicotineadministrationinducedchangesinthegonadalfunctionsinmalerats[j].pharmacol,1999,58(1):2-7
|
| [3] | 11tyndalerf,sellersem.variablecyp2a6-mediatednicotinemetabolismalterssmokingbehaviorandrisk[j].drugmetabdispos,2001,29(4):48-52
|
| [4] | 12pausovaz,paust,sedovai,berubej.prenatalexposuretonicotinemodifieskidneyweightandbloodpressureingeneticallysusceptiblerats;acaseofgene-environmentinteraction[j].kidneyint,2003,64(3):829-835
|
| [5] | 13crookspa,dwoskinlp.contributionofcnsnicotinemetabolitestotheneuropharmacologicaleffectsofnicotineandtobaccosmoking[j].biochempharmacol,1997,54:743-753
|
| [6] | 14serobyann,orlovskayai,kozlovv,khaldoyanidisk.exposuretonicotineduringgestationinterfereswiththecolonizationoffetalbonemarrowbyhematopoieticstem/progenitorcells[j].stemcellsdev,2005,14(1):81-91
|
| [7] | 15ochiaiy,sakuraie,nomura,itohk,takanay.metabolismofnicotineinratlungmicrovascularendothelialcells[j].jpharmpharmacol,2006,58(3):403-407
|
| [8] | 16el-zayadiar.heavysmokingandliver[j].worldjgestroenterol,2006,12(38):6098-6101
|
| [9] | 17yuenst,gogoar,lukis,choch,hojc,lohtt.theeffectofnicotineanditsinteractionwithcarbontetrachlorideintheratliver[j].pharmacoltoxicol,1995,77(3):225-230
|
| [10] | 19al-qarawiaa,mousahm,alibeh,abdel-rahmanh,el-mougysa.protectiveeffectofextractsfromdates(phoenixdactyliferal.)oncarbontetrachlorideinducedhepatotoxicity[j].intjapplresvetmed,2004,2:176-180
|
| [11] | 21copleyms,rosepj,clamphama,edwardsdn,hortonmc,evershedrp.detectionofpalmfruitlipidsinarchaeologicalpotteryfromqasribrim,egyptiannuba[j].procrsoclondon,2001,268:593-597
|
| [12] | 22al-farsima,leecy.nutritionalandfunctionalpropertiesofdates:areview[j].criticalrevfoodscinutr,2008,48(10):877-887
|
| [13] | 23al-maimansa.effectofdatepalm(phoenixdactylifera)seedfibersonplasmalipidsinrats[j].jkingsaudunivagrisci,2005,17:117-123
|
| [14] | 24hussainas,alhadramiga,khalilyh.theuseofdateanddatepitinboilerstarterandfinisherdiets[j].bioresourcetechnol,1998,66(3):219-223
|
| [15] | 27vayalilpk.antioxidantandantimutagenicpropertiesofaqueousextractdatefruit(phoenixdactyliferal.arecaceae)[j].jagricfoodchem,2002,50(3):610-617
|
| [16] | 28mohammedba,nabilah,hananas.protectiveeffectsofextractfromdates(phoenixdactyliferal.)andascorbicacidonthioacetamide-inducedhepatotoxicityinrats[j].iranianjpharmares,2008,7(3):193-201
|
| [17] | 29bancroftjd,gamblem.theoryandpracticalofhistologicaltechniques.5thed.edinburgh:churchilllivingstone,1977
|
| [18] | 30hoffmannd,rivensona,hechtss.thebiologicalsignificanceoftobacco-specificn-nitrosamines:smokingandadenocarcinomaofthelungs[j].critrevtoxicol,1996,26(2):199-211
|
| [19] | 31shawm,mitchellr,dorlingd.timeforasmoke?onecigarettereducesyourlifeby11min[j].bmj,2000,320(1):53-59
|
| [20] | 32ghalyma,khedres,aleemaa.acomparativestudyofnicotineeffectontheliverofalbinorat[j].egyptianjhospitalmed,2002,10(9):130-144
|
| [21] | 33el-sokkarygh,cuzzocreas,reiterrj.effectsofchronicnicotineadministrationontheratlungandliver:beneficialroleofmelatonin[j].toxicol,2007,239:60-67
|
| [22] | 34gawisham,issaam,bassilyns,manaasm.roleofgreenteaonnicotinetoxicityonliverandlungsofmice:histologicalandmorphometricstudies[j].afrjbiotechnol,2012,11(8):2013-2025
|
| [23] | 35neogys,dass,mahapatrask,mandaln,roys.amelioratoryeffectofandrographispaniculataneesonliver,kidney,heart,lungsandspleenduringnicotineinducedoxidativestress[j].environtoxicolpharmacol,2008,25(3):321-328
|
| [24] | 36kovacicp,cooksya.iminiummetabolitemechanismfornicotinetoxicityandaddiction:oxidativestressandelectrontransfer[j].medhypotheses,2005,64(1):104-111
|
| [25] | 37shenghp,yuenst,sohl,choch.hepatotoxicityofprenatalandpostnatalexposuretonicotineinratpups[j].expbiolmed,2001,226(10):934-939
|
| [26] | 38mansouria,embarekg,kokkaloue,kefalasp.phenolicprofileandantioxidantactivityofthealgerianripedatepalmfruit(pheonixdectylifera)[j].foodchem,2005,89(3):411-420
|
| [27] | 39saafieb,louedim,elfekia,zakhamaa,najjarmf,hammamim,achourl.protectiveeffectofdatepalmfruitextract(phoenixdactyliferal.)ondimethoateinducedoxidativestressinratliver[j].exptoxicolpathol,2010,64(5):433-441
|
| [28] | 1yildizd.nicotine,itsmetabolismandanoverviewofitsbiologicaleffects[j].toxicon,2004,43(6):619-632
|
| [29] | 2trushinn,hechtss.stereoselectivemetabolismofnicotineandtobaccospecificn-nitrosaminesto4-hydroxy-4-(3-pyridy)butanoicacidinrats[j].chemrestoxicol,1999,12(2):164-171
|
| [30] | 3balfourd,benowitzn,fagerstromk,kunzem,keilu.diagnosisandtreatmentofnicotinedependencewithemphasisonnicotinereplacementtherapy.astatusreport[j].eurheartj,2000,21(6):438-445
|
| [31] | 4lehouezecj.roleofnicotinepharmacokineticsinnicotineaddictionandnicotinereplacementtherapy[j].intjtuberclungdis,2003,7(9):811-819
|
| [32] | 5danija.heinemanns.molecularandcellularaspectsofnicotineabuse[j].neuron,1996,16(5):905-908
|
| [33] | 6okamotom,kitat,okudah,tanakat,nakashimat.effectsofagingonacutetoxicityofnicotineinrats[j].pharmacoltoxicol,1994,75(1):1-6
|
| [34] | 7valencass,gouveial,pimentawa.portolc.effectsoforalnicotineonratliverstereology[j].intjmorphol,2008,26(4):1013-1022
|
| [35] | 9nakajimam,yokoit.interindividualvariabilityinnicotinemetabolism:c-oxidationandglucuronidation[j].drugmetabpharmacokinet,2005,20(4):227-235
|
| [36] | 18husaink,scottbr,reddysk,somanism.chronicethanolandnicotineinteractiononrattissueantioxidantdefensesystem[j].alcohol,2001,25(2):89-97
|
| [37] | 20vyawaharens,pujarirr,rajendranr,khsirsagarad,ingawaledk,patilmn.neurobehavioraleffectsofphoenixdactyliferainmice[j].jpharmacol,2009,1(3):225-232
|
| [38] | 25puria,sahair,singhkl,sexenarp,tandonjs,sexenakc.immunostimulantactivityofdryfruitsandplantmaterialsusedintheindiantraditionalmedicalsystemformothersafterchildbirthandinvalids[j].j.ethopharmacol,2000,71(1-2):89-92
|
| [39] | 26al-qarawiaa,abdel-rahmanh,mousahm,alibh,el-mougysa.nephroprotectiveactionofphoenixdectyliferaingentamicininducednepherotoxicity[j].pharmabiol,2008,46:227-230
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
