%0 Journal Article
%T nicotineinducedhepatotoxicityanditspreventionwithdatepalmpitpowder
%A bushramunir
%A mohammadtahir
%A sobiamunir
%A muhammadnawazchaudhry
%A abdulqadir
%J 应用与环境生物学报
%P 489-493
%D 2015
%R 10.3724/SP.J.1145.2014.09005
%X cigarettesmokingiscommoninsocietiesworldwideandhasbeenidentifiedasinjurioustohumanhealth.nicotineisthemostabundantcomponentinthecigarettesmoke.itisfirstmetabolizedintheliver.thenaturaldietcontainsavarietyofcompounds,suchasdatepalm(phoenixdactyliferal.).itexhibitsprotectiveeffectagainstdifferenttoxins.theaimsofpresentstudyweretoinvestigatethedamagingeffectsofnicotineontheliverandthepreventiveroleofdatepalmagainstsuchdamage.datepalmpitpowderwasusedtostudyitsprotectiveeffectonnicotineinducedhepatotoxicity.threegroupsofadultmalealbinomicewereused,eachcontainingeightanimals.groupaservedasacontrol;groupbwasusedasanexperimentalgrouptreatedwithnicotine(0.3mg/kg)intraperitoneallyforforty-fivedays;groupcreceivednicotine(0.3mg/kg)intraperitoneallyalongwithdatepalmpitpowder(500mg/kg)orallyforforty-fivedays.histopathologicalexaminationrevealedthatthegeneralarchitecturewasdamagedwithincreaseinsizeofhepatocytes,centralveinandnumberoffatvacuolesandperiportalinfiltrationoflymphocytes.thenicotinetreatedmiceshoweddecreasedlevelofcytoplasmicvacuolization,necrosisandinflammation.datepalmpitpowderadministrationtonicotine-treatedmiceshowedreversionofthedamagedfeaturetonearlynormal.theseresultsalongwithpreviousstudysuggestthatdatepalmpitpowderisusefulincombatingnicotineinducedhepatotoxicity.
%K nicotine
%K hepatotxicity
%K datepalmpitpowder
%U http://www.cibj.com/oa/DArticle.aspx?type=view&id=201409005