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OALib Journal期刊
ISSN: 2333-9721
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米曲霉氨基酰化酶酶法拆分制备d型芳香族氨基酸
DOI: 10.3724/SP.J.1145.2009.00734, PP. 734-736
Keywords: 米曲霉,氨基酰化酶,苯丙氨酸,d型芳香族氨基酸,酶法拆分
Abstract:
以dl-苯丙氨酸为起始原料，乙酸酐乙酰化后得到n-乙酰dl-苯丙氨酸，利用米曲霉氨基酰化酶立体结构专一催化水解n-酰基-l-氨基酸的酰胺键的特点，分别得到l-苯丙氨酸和n-乙酰d-苯丙氨酸.通过结晶法分离两者后，n-乙酰d-苯丙氨酸经6mol/lhcl水解得到d-苯丙氨酸.由此拆分dl-苯丙氨酸得到光学纯度分别为98%的l-苯丙氨酸(收率84.8%，以原料n-乙酰-dl-苯丙氨酸的0.5倍摩尔量为理论产率)和92.3%的d-苯丙氨酸(收率89.5%).参22
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