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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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抗生素开发的新靶点：核糖开关
, PP. 1361-1368
Keywords: 核糖开关,耐药性,抗生素
Abstract:
核糖开关是位于mrna区域的特定片段,被小分子配体激活后即可顺式调控基因表达,无需蛋白参与。经进化选择,大部分细菌内核糖开关采用必需代谢产物为配体,负责调控与配体生物合成或转运相关基因的表达。代谢产物类似物可以抑制核糖开关介导的基因表达,抑制细菌生长,甚至引起细菌死亡,因此核糖开关可以作为抗生素开发的新靶点。已经发现的几种先导化合物显示了以核糖开关为靶点的开发潜力。本文简要阐述了可以作为抗生素靶点的核糖开关及其作用机制,介绍了以核糖开关为靶点的新型抗生素高通量筛选及药物设计方法,并对可能遇到的困难进行了分析。
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