invitro-invivocorrelationstudyofnimesulideloadedhydroxypropylmethylcellulosemicroparticles

thisstudyinvolvesmathematicalsimulationmodelsuchasinvitro-invivocorrelation(ivivc)developmentforvariousextendedreleaseformulationsofnimesulideloadedhydroxypropylmethylcellulose(hpmc)microparticles(m1,m2andm3containing1,2,and3ghpmc,respectivelyand1gdrugineach)？havingvariablereleasecharacteristics.？invitrodissolutiondataoftheseformulationswerecorrelatedtotheirrelevantinvivoabsorptionprofilesfollowedbypredictabilityworthanalysisoftheselevelaivivc.？nimaranwasusedascontrolformulationtovalidatedevelopedformulationsandtheirrespectivemodels.？theregressioncoefficientsofivivcplotsform1,m2,m3andnimaranwere0.8349,0.8312,0.9272and0.8981,respectively.？theinternalpredictionerrorforallformulationswaswithinlimits,i.e.,<10%.？agoodivivcwasfoundforcontrolledreleasenimesulideloadedhpmcfloatingm3microparticles.？inotherwords,thismathematicalsimulationmodelisbestfitforbiowaiverstudieswhichinvolvesstudyparametersasthoseadoptedform3？？becausethevalueofitsivivcregressioncoefficientistheclosestto1ascomparedtom1andm2.