%0 Journal Article
%T invitro-invivocorrelationstudyofnimesulideloadedhydroxypropylmethylcellulosemicroparticles
%J ҩѧѧ±¨
%P 772-777
%D 2010
%X thisstudyinvolvesmathematicalsimulationmodelsuchasinvitro-invivocorrelation(ivivc)developmentforvariousextendedreleaseformulationsofnimesulideloadedhydroxypropylmethylcellulose(hpmc)microparticles(m1,m2andm3containing1,2,and3ghpmc,respectivelyand1gdrugineach)£¿havingvariablereleasecharacteristics.£¿invitrodissolutiondataoftheseformulationswerecorrelatedtotheirrelevantinvivoabsorptionprofilesfollowedbypredictabilityworthanalysisoftheselevelaivivc.£¿nimaranwasusedascontrolformulationtovalidatedevelopedformulationsandtheirrespectivemodels.£¿theregressioncoefficientsofivivcplotsform1,m2,m3andnimaranwere0.8349,0.8312,0.9272and0.8981,respectively.£¿theinternalpredictionerrorforallformulationswaswithinlimits,i.e.,<10%.£¿agoodivivcwasfoundforcontrolledreleasenimesulideloadedhpmcfloatingm3microparticles.£¿inotherwords,thismathematicalsimulationmodelisbestfitforbiowaiverstudieswhichinvolvesstudyparametersasthoseadoptedform3£¿£¿becausethevalueofitsivivcregressioncoefficientistheclosestto1ascomparedtom1andm2.
%U http://www.yxxb.com.cn:8081/aps/CN/abstract/abstract13730.shtml