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药学学报 2011
preparationoffluconazolebuccaltabletandinfluenceofformulationexpedientsonitsproperties, PP. 460-465 Abstract: theaimofpresentstudywastopreparebuccaltabletsoffluconazolefororalcandidiasis.？thedosageformsweredesignedtoreleasethedrugabovetheminimuminhibitoryconcentrationforprolongedperiodoftimesoastoreducethefrequencyofadministrationandtoovercomethesideeffectsofsystemictreatment.？thebuccaltabletswerepreparedbyusingcarbopol71gandnoveonaa-1bydirectcompressionmethod.？microcrystallinecellulosewasusedasthefilleranditseffectwasalsostudied.？theprepareddosageformswereevaluatedforphysicochemicalproperties,invitroreleasestudiesandmucoadhesivepropertiesusingsheepbuccalmucosaasamodeltissue.？tabletscontaining50%ofpolymers(carbopol&noveon)werefoundtobethebestwithmoderateswellingalongwithfavorablebioadhesionforce,residencetimeandinvitrodrugrelease.？theinvitrodrugreleasestudiesrevealedthatdrugreleasedfor8h,whichinturnmayreducedosingfrequencyandimprovedpatientcomplianceinoralcandidiasispatients.
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