%0 Journal Article
%T preparationoffluconazolebuccaltabletandinfluenceofformulationexpedientsonitsproperties
%A mohamed
%A saifulla
%A p*
%A muzzammil
%A shariff
%A pramod
%A kumar
%A tm
%J ҩѧѧ±¨
%P 460-465
%D 2011
%X theaimofpresentstudywastopreparebuccaltabletsoffluconazolefororalcandidiasis.£¿thedosageformsweredesignedtoreleasethedrugabovetheminimuminhibitoryconcentrationforprolongedperiodoftimesoastoreducethefrequencyofadministrationandtoovercomethesideeffectsofsystemictreatment.£¿thebuccaltabletswerepreparedbyusingcarbopol71gandnoveonaa-1bydirectcompressionmethod.£¿microcrystallinecellulosewasusedasthefilleranditseffectwasalsostudied.£¿theprepareddosageformswereevaluatedforphysicochemicalproperties,invitroreleasestudiesandmucoadhesivepropertiesusingsheepbuccalmucosaasamodeltissue.£¿tabletscontaining50%ofpolymers(carbopol&noveon)werefoundtobethebestwithmoderateswellingalongwithfavorablebioadhesionforce,residencetimeandinvitrodrugrelease.£¿theinvitrodrugreleasestudiesrevealedthatdrugreleasedfor8h,whichinturnmayreducedosingfrequencyandimprovedpatientcomplianceinoralcandidiasispatients.
%U http://www.yxxb.com.cn:8081/aps/CN/abstract/abstract13942.shtml