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营养与鱼类免疫研究进展

DOI: 10.3969/j.issn.1006-267x.2014.10.032

Keywords: 营养物质,鱼类,免疫防御,抗氧化防御,细胞因子,TOR信号途径,Nrf2信号途径

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Abstract:

鱼类生长发育与疾病抵抗力密切相关,而营养物质在鱼类疾病抵抗力及其免疫调控中发挥着重要作用。已有研究表明部分营养物质可通过雷帕霉素靶蛋白(TOR)和核因子E2相关因子2(Nrf2)信号途径调控鱼类免疫器官细胞因子产生,降低鱼类免疫器官氧化损伤,从而保证其结构完整性和功能正常,进而提高鱼类非特异性和特异性免疫力,增强鱼类疾病抵抗力。本文就部分氨基酸(蛋氨酸和异亮氨酸)、脂溶性维生素(维生素A)、水溶性维生素(维生素B1、吡哆醇、泛酸、胆碱和肌醇)以及营养性添加物(蛋氨酸羟基类似物)等营养物质与鱼类疾病抵抗力、非特异和特异性免疫防御、免疫器官生长发育、结构完整性和抗氧化防御、细胞因子及其相关信号途径之间关系的研究进展作一综述。

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