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家禽肠道屏障功能及其营养调控

DOI: 10.3969/j.issn.1006-267x.2014.10.021

Keywords: 家禽,肠道屏障,紧密连接蛋白,营养调控

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Abstract:

肠道具有双重功能,既作为消化和吸收营养物质的重要器官,又是保持机体内环境稳定的先天性屏障。家禽肠道屏障包括机械屏障、化学屏障、微生物屏障和免疫屏障。目前,测定肠道屏障功能的方法包括检测肠道通透性、血浆内毒素、细菌移位、肠道黏膜组织学观察等。有限的研究报道了肠道屏障功能及紧密连接蛋白的闭锁蛋白occludin、闭合蛋白claudins(claudin-3、-5、-16)和闭合小环蛋白(ZO)-2在胚胎期和/或出壳后早期在鸡肠上皮的发育模式,并认为不同肠段的屏障功能及其紧密连接蛋白的发育速度很不一致。家禽肠道屏障的营养调控方面的研究主要涉及营养素(如锌)、胃肠道微生态制剂(如益生菌和益生元)、功能性多糖、表皮生长因子和酶制剂等添加剂的作用。谷氨酰胺和苏氨酸等添加剂虽对其他动物屏障功能有作用,但对家禽肠道屏障的作用还有待证实。本文对家禽肠道屏障理论研究和应用技术进行了综述与展望。

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