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氟苯尼考颗粒与氟苯尼考粉在猪体内的药物动力学比较

DOI: 10.7671/j.issn.1001-411X.2012.02.024, PP. 235-238

Keywords: 氟苯尼考,颗粒,粉剂,猪,药物动力学

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Abstract:

健康猪14头随机分为A、B2组，分别单剂量胃管灌服氟苯尼考粉和颗粒，按体质量给药剂量均为30mg/kg，进行比较药动学研究.高效液相色谱法（HPLC）测定其血药浓度.采用药动学分析软件WinNonlin5.2.1的非房室模型处理血药浓度-时间数据.氟苯尼考粉灌胃给药的主要药物动力学参数为：t1/2β=（10.22±0.18）h，ke=（0.07±0.01）h-1，tmax=（1.67±0.48）h，Cmax=（24.68±1.13）μg·mL-1，AUC=（190.97±16.60）μg·mL-1·h，MRT=(8.33±0.42)h，tcp=（17.66±1.52）h.氟苯尼考颗粒灌胃给药的主要药物动力学参数为：t1/2β=（16.36±4.14）h，ke=（0.05±0.01）h-1，tmax=(5.71±0.47)h，Cmax=(12.23±0.78)μg·mL-1，AUC=（155.44±6.59）μg·mL-1·h，MRT=(14.96±0.35)h，tcp=（23.03±0.49）h.试验结果表明，与氟苯尼考粉相比，氟苯尼考颗粒的消除半衰期更长，有效血药浓度维持时间也较长.

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