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基于局部结构交互的RNA假结预测

, PP. 613-618

Keywords: 计算机应用,RNA二级结构,假结,最小自由能,交互配对

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Abstract:

基于RNA局部结构间的交互作用,提出一种含假结的RNA二级结构预测新方法LIFold。对给定的RNA序列,首先通过能量计算得到不含假结的能量最优结构,然后应用局部结构交互配对生成假结茎区,在已得到的最优结构基础上构建含假结的能量计算模型,最后通过优化算法得到含假结的RNA二级结构。应用该方法基于HotKnots测试数据的敏感性和阳性预测值(PPV)分别达到84%和80%,基于PseudoBase数据库测试数据的敏感性和阳性预测值分别达到78%和73%,与HotKnots、ILM、PknotsRG、IPknot及FlexStem等知名软件相比较,准确率均有所提高。

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