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华西医学  2010 

吉非替尼治疗突变未知的终末期非小细胞肺癌的临床观察

, PP. 1423-1425

Keywords: 肺癌,吉非替尼,突变未知,生活质量

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Abstract:

【】目的评估吉非替尼治疗终末期(PS评分≥3分)非小细胞肺癌(NSCLC)的临床效果和生活质量改善情况。方法2008年5月-2010年6月共收治终末期NSCLC患者40例,其中19例患者采用吉非替尼治疗(治疗组),21例采用支持治疗+中药治疗(对照组)。结果治疗6个月后,治疗组19例患者中,CR1例,PR5例,SD10例,PD3例。治疗组有效率为31.5%(6/19),临床受益率为84.2%(16/19)。对照组21例中,SD5例,PD16例,无CR。对照组有效率为23.8%(5/21),临床受益率为23.8%(5/21)。两组间有效率和临床受益率比较,差异均有统计学意义(P<0.05)。治疗组中位生存期为13.2个月,对照组中位生存期为4.5个月。结论吉非替尼可延长NSCLC患者的生存期,改善其生活质量。?【Abstract】ObjectiveToevaluatethecurativeeffectandlifeimprovementofgefitinibonnon-smallcelllungcancer(NSCLC)whichintheendstage.MethodsFortypatientswithend-stageNSCLCweretreatedfromMay2008toJune2010.Nineteenpatientsofthemweretreatedwithgefitinib(treatmentgroup),21patientsweretreatedwithsupportivecareandtraditionalChinesemedicinetreatment(controlgroup).ResultsSixmonthsaftertreatment,thereareonepatientwithCR,fivepatientswithPR,10patientswithSDandthreepatientswithPDinthetreatmentgroup.Theeffectiverateoftreatmentgroupwas31.5%(6/19),clinicalbenefitratewas84.2%(16/19).TherearefivepatientswithSD,16patientswithPD,andnoonewithCRinthecontrolgroup.Theeffectiverateofthecontrolgroupwas23.8%(5/21),clinicalbenefitratewas23.8%(5/21).Thedifferencesofeffectiverateandclinicalbenefitratebetweentwogroupswerestatisticallysignificant(P<0.05).Themediansurvivalperiodofthetreatmentgroupandcontrolgroupwere13.2and4.5monthsrespectively.ConclusionGefitinibcanextendthelifetimeofNSCLCpatientsandimprovetheirqualityoflife.

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