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华西医学  2011 

自体造血干细胞移植治疗侵袭性NK/T细胞淋巴瘤

, PP. 1763-1766

Keywords: 侵袭性NK/T细胞淋巴瘤,自体造血干细胞移植,治疗

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Abstract:

【】 目的 探讨自体造血干细胞移植(autologoushematopoieticstemcelltransplantation,auto-HSCT)治疗侵袭性NK/T细胞淋巴瘤的疗效。 方法 对我科2005年1月16日收治的1例侵袭性NK/T细胞淋巴瘤患者的造血干细胞移植和随访资料进行回顾性分析,并复习国内外相关文献。 结果 患者为37岁女性,诊断结外鼻型NK/T细胞淋巴瘤,系统性,经CHOAP和ICE方案化学疗法、手术、局部放射治疗控制病情良好后,采集自体骨髓造血干细胞,行auto-HSCT,预处理方案为全身放射治疗+ECy;移植+29d造血功能即顺利重建;移植后密切随访,患者一直处于完全缓解,至今已存活67个月。 结论 auto-HSCT治疗侵袭性NK/T细胞淋巴瘤疗效肯定、可靠。【Abstract】 Objective Toexplorethetherapeuticeffectofautologoushematopoieticstemcelltransplantation(auto-HSCT)onaggressiveNK/Tlymphoma. Methods TheclinicaldataofonepatientwithaggressiveNK/TlymphomadiagnosedinJanuary2005wereretrospectivelyanalyzed,andtherelevantdomesticliteratureswereanalyzed. Results Thisthirty-seven-year-oldfemalepatienthadgooddiseasecontrolafterundergoingchemotherapywithCHOAPandICEregimens,surgery,andlocoregionalradiotherapy.Afterthat,shehadbeencollectedenoughbonemarrow-derivedhematopoieticstemcells,thenunderwentauto-HSCTwiththesecells.TheconditioningregimenwasTBIplusECy.Onthe+29thdayaftertransplantation,thehematopoieticreconstructionwassuccessful.Duringthefollow-upperiod,thepatientwasincompleteremissionstatusallalongandherdisease-freesurvival(DFS)was67months. Conclusion Auto-HSCTiseffectiveonaggressiveNK/Tlymphoma.

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