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华西医学  2011 

腰池置管脑脊液外引流治疗颅内感染临床分析

, PP. 359-361

Keywords: 持续腰池置管,脑脊液外引流,颅内感染

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Abstract:

 方法 2008年9月-2009年11月,将20例颅脑外伤后颅内感染患者分为脑脊液外引流组和抗生素组各10例,外引流组进行持续腰池置管脑脊液外引流,定期取引流脑脊液进行常规和生化检查;抗生素组采用静脉抗生素治疗。对两组颅内感染情况进行对比分析。 结果 外引流组经持续腰池置管脑脊液外引流治疗后,颅内感染临床症状明显缓解,脑脊液有核细胞数和脑脊液微量蛋白含量显著降低、脑脊液葡萄糖和氯化物浓度升高(P<0.05)。治疗10d后,外引流组体温、脑脊液有核细胞数、脑脊液微量蛋白含量、脑脊液葡萄糖和氯化物浓度的改善程度明显优于抗生素组(P<0.05)。 结论 持续腰池置管脑脊液外引流治疗颅内感染具有安全性高、操作简便、观察颅内感染情况方便的优点,可作为颅内感染可靠治疗手段。【Abstract】 Objective Toobservetheefficacyofcontinuouslumbardrainageofcerebrospinalfluidviaalumbarcatheterintreatingintracranialinfection. Methods FromSeptember2008toNovember2009,20patientswithintracranialinfectionafterheadtraumawereenrolledinthisstudy.Tenofthem,classifiedastheexternaldrainagegroup,sustainedcontinuousexternallumbardrainageofcerebrospinalfluid.Thecerebrospinalfluidwasobtainedregularlyforroutineandbiochemicalexamination.Theother10patientswerecategorizedastheantibioticsgroup.Theyonlyacceptedintravenousantibiotictherapy. Results Forthepatientsintheexternaldrainagegoup,aftercontinuousexternallumbardrainageofcerebrospinalfluid,theirclinicalsymptomsofintracranialinfectionweresignificantlyalleviatedandthenumberofnucleatedcellsandproteincontentinthecerebrospinalfluiddecreasedsignificantly,whiletheglucoseandchlorideconcentrationsincreasedsignificantly(P<0.05).After10daysoftreatment,thepatientsintheexternaldrainagegroupweresuperiortothoseintheantibioticsgroupinimprovementofthebodytemperature,thenumberofnucleatedcellsandproteincontent,glucoseandchlorideconcentrationsinthecerebrospinalfluid(P<0.05). Conclusion Continuouslumbardrainageofcerebrospinalfluidissimpleandsafe.Itprovidesaneasywayofmonitoringtheintracranialinfectionandcanbeareliabletreatment.

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