Proliferative Activity (Ki-67 Expression) and Outcome in High Grade Osteosarcoma: A Study of 27 Cases

Purpose. Although pre-operative chemotherapy has improved the prognosis for individuals with osteosarcoma, approximately 40% of patients will die of their disease.The aim of this study was to quantitate proliferative activity in high grade osteosarcomas and to determine whether proliferation is a prognostic factor.