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过程工程学报 2010
StorageStabilityofAlpha-LipoicAcid-loadedLipidNanoparticlesKeywords: alpha-lipoicacid,lipidnanoparticles,storagestability,particlesize,particlemorphology Abstract: Alpha-lipoicacid-loadedlipidnanoparticles(ALA-LNs)werepreparedbyhighpressurehomogenizationmethod.TheinfluencesofstorageconditionssuchastimeandtemperatureonthephysicalandchemicalstoragestabilityofALA-LNswerestudiedindetails.Thestabilitywasevaluatedbyparticlesizeandpolydispersityindex,morphologyofALA-LNs,andcapacityofALAloading.ThedilutionandpHstabilityofALA-LNssuspensionswerealsostudied.Afterthreemonthsstorage,themeansizeofALA-LNsat4and40℃wasincreasedby2.68%and3.62%comparedwiththeoriginalsize,respectively.ALA-LNsstoredat40℃hadellipsoidshapeandthemeansizewasabout152nm(SD=23.6).TheloadingcapacityofALAat40℃wasmuchhigherthanthosestoredatothertwotemperatures.ThegooddilutionandpHstabilitywerealsodemonstrated.Thesamplehadgoodfluidityevenat4℃.
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