%0 Journal Article
%T StorageStabilityofAlpha-LipoicAcid-loadedLipidNanoparticles
%A 唐金国
%A 夏强
%A 刘光煜
%J 过程工程学报
%D 2010
%X Alpha-lipoicacid-loadedlipidnanoparticles(ALA-LNs)werepreparedbyhighpressurehomogenizationmethod.TheinfluencesofstorageconditionssuchastimeandtemperatureonthephysicalandchemicalstoragestabilityofALA-LNswerestudiedindetails.Thestabilitywasevaluatedbyparticlesizeandpolydispersityindex,morphologyofALA-LNs,andcapacityofALAloading.ThedilutionandpHstabilityofALA-LNssuspensionswerealsostudied.Afterthreemonthsstorage,themeansizeofALA-LNsat4and40℃wasincreasedby2.68%and3.62%comparedwiththeoriginalsize,respectively.ALA-LNsstoredat40℃hadellipsoidshapeandthemeansizewasabout152nm(SD=23.6).TheloadingcapacityofALAat40℃wasmuchhigherthanthosestoredatothertwotemperatures.ThegooddilutionandpHstabilitywerealsodemonstrated.Thesamplehadgoodfluidityevenat4℃.
%K alpha-lipoicacid
%K lipidnanoparticles
%K storagestability
%K particlesize
%K particlemorphology
%U http://www.jproeng.com/qikan/Cpaper/zhaiyao.asp?bsid=15432