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生物活性环肽PaecilodepsipeptideA的全合成

Keywords: Paecilodepsipeptide,A,环肽,全合成

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Abstract:

首次采用逆合成法对昆虫病原真菌PaecilomycescinnamomeusBCC9616中分离的高活性抗肿瘤环己肽环肽PaecilodepsipeptideA进行了全合成.采用标准肽化学合成方法,完成了五肽的合成;以酪氨酸甲酯盐酸盐为起始原料,得到O-异戊烯基-D-酪氨酸衍生物;通过五肽与O-异戊烯基-D-酪氨酸衍生物的酯化反应得到环化前体;采取大环内酰氨化和大环内酯化的策略进行关环,完成了天然产物PaecilodepsipeptideA的全合成,产率72%.目标化合物经质谱与核磁共振光谱结构确证与天然产物一致.

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