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辛伐他汀抑制K562细胞MAPK1、cyclinD1、E2F1、c-mycmRNA的表达

, PP. 241-244

Keywords: 辛伐他汀,K细胞,MAPK,cyclinD,EF,c-myc

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Abstract:

目的探讨辛伐他汀抑制K562细胞增殖并诱导其凋亡的分子机制。方法不同浓度辛伐他汀作用K562细胞后,MTT法检测细胞增殖情况,AnnexinⅤ-FITC/PI双染法检测细胞凋亡情况,RT-PCR测定MAPK1、cyclinD1、E2F1、c-mycmRNA表达。结果辛伐他汀能抑制K562细胞增殖,增殖抑制效应随药物浓度增加和作用时间延长而增大(P<0.05)。与对照组比较,5、10、20μmol/L辛伐他汀作用K562细胞48h和72h后能明显增加细胞凋亡率,差异具有统计学意义(P<0.05),表明辛伐他汀能诱导K562细胞凋亡。10、20μmol/L辛伐他汀处理K562细胞72h后,MAPK1、cyclinD1、E2F1、c-mycmRNA表达水平明显降低。结论辛伐他汀可能通过调节Ras-MAPK途径抑制K562细胞增殖并诱导其凋亡。

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