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白藜芦醇减轻脑缺血再灌注损伤及其机制

, PP. 2586-2590

Keywords: 白藜芦醇,脑缺血再灌注,氧化应激,Nrf,HO-

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Abstract:

目的研究白藜芦醇(Res)对脑缺血再灌注损伤的保护作用及可能的机制。方法线栓法制作大鼠大脑中动脉栓塞(middlecerebralarteryocclusion,MCAO)模型,缺血2h再灌注。将76只大鼠分成假手术组(S组)、缺血再灌注组(I/R组)、Res低剂量组(15mg/kg,I/R+R1组)和Res高剂量组(30mg/kg,I/R+R2组),每组19只。再灌注24h,采用TTC法测量脑梗死体积,化学比色法测定血清及脑组织中MDA含量,RT-PCR及Westernblot检测Nrf2、HO-1基因和蛋白表达,HE染色观察脑组织的病理改变。结果与I/R组比较,Res能明显缩小脑梗死体积[I/R组(42.67±2.51)%vsI/R+R1组(30.53±1.45)%、I/R+R2组(20.27±2.11)%,P<0.01],降低血清中MDA的含量[I/R组(9.29±0.42)nmol/mlvsI/R+R1组(4.03±0.08)nmol/ml、I/R+R2组(2.68±0.27)nmol/ml,P<0.01],及脑组织中MAD含量[I/R组(1.40±0.02)nmol/mgvsIR+R1组(1.19±0.07)nmol/mg、IR+R2组(0.85±0.03)nmol/mg,P<0.01]。显著上调Nrf2、HO-1基因和蛋白的表达(P<0.05),改善脑组织的病理变化。结论Res对局灶性脑缺血再灌注损伤有良好的保护作用,其机制可能是通过激活Nrf2/ARE信号通路进而增强抗氧化蛋白HO-1表达实现的。

References

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