Lekawanvijit S, Adrahtas A, Kelly D J, et al. Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?[J]. Eur Heart J, 2010, 31(14): 1771-1779. ？ [2]Liu S, Wang B H, Kompa A R, et al. Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate[J]. Int J Cardiol, 2012, 158(3): 457-458. ？ [3]Yisireyili M, Shimizu H, Saito S, et al. Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats[J]. Life Sci, 2013, 92(24/26): 1180-1185. ？ [4]杨可, 孙蕾, 管旭, 等. 硫酸吲哚酚诱导心肌细胞肥大的研究[J]. 第三军医大学学报, 2013, 35(24): 2630-2633. [5]Mall G, Huther W, Schneider J, et al. Diffuse intermyocardiocytic fibrosis in uraemic patients[J]. Nephrol Dial Transplant, 1990, 5(1): 39-44. ？ [6]Amann K, Buzello M, Simonaviciene A, et al. Capillary/myocyte mismatch in the heart in renal failure--a role for erythropoietin?[J]. Nephrol Dial Transplant, 2000, 15(7): 964-969. ？ [7]Berl T, Henrich W. Kidney-heart interactions: epidemiology, pathogenesis, and treatment[J]. Clin J Am Soc Nephrol, 2006, 1(1): 8-18. [8]Meert N, Schepers E, De-Smet R, et al. Inconsistency of reported uremic toxin concentrations[J]. Artif Organs, 2007, 31(8): 600-611. [9]Fujii H, Nishijima F, Goto S, et al. Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress[J]. Nephrol Dial Transplant, 2009, 24(7): 2089-2095. [10]Strom C C, Aplin M, Ploug T, et al. Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy[J]. FEBS J, 2005, 272(11): 2684-2695. ？ [11]Bodyak N, Rigor D L, Chen Y S, et al. Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes[J]. Am J Physiol Heart Circ Physiol, 2007, 293(1): H829-H835. ？ [12]Dromparis P, Paulin R, Sutendra G, et al. Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension[J]. Circ Res, 2013, 113(2): 126-136. ？ [13]Sun J, Pu Y, Wang P, et al. TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction[J]. Cardiovasc Diabetol, 2013, 12: 69. ？ [14]Zhang Y, Li L, Hua Y, et al. Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction[J]. J Mol Cell Biol, 2012, 4(2): 97-107. ？ [15]Tian X Y, Wong W T, Xu A, et al. Uncoupling protein-2 protects endothelial function in diet-induced obese mice[J]. Circ Res, 2012, 110(9): 1211-1216. ？ [16]Negre-Salvayre A, Hirtz C, Carrera G, et al. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation[J]. FASEB J, 1997, 11(10): 809-815. ？ [17]Teshima Y, Akao M, Jones S P, et al. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes[J]. Circ Res, 2003, 93(3): 192-200. ？ [18]Xu M J, Song P, Shirwany N, et al. Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunits[J]. Arterioscler Thromb Vasc Biol, 2011, 31(8): 1757-1765.
