Goldstein J L,Brown M S. Regulation of the mevalonate pathway[J].Nature,1990,343:425.
[5]
Robinson G W,Tsay Y H,Kienzle B K,et al. Conservation between human and fungal squalene synthetases:similarities in structure, function, and regulation[J]. Mol Cell Biol,1993,13(5):2706.
[6]
Okada S,Devarenne T P,Chappell J. Molecular characterization of squalene synthase from the green microalga Botryococ cusbraunii, race B[J]. Arch Biochem Biophys,2000,373(2):307.
Chappell J. Biochemistry and molecular biology of the isoprenoid biosynthetic pathway in plants [J].Annu Rev Plant Biol,1995,46(1):521.
[11]
Estévez J M,Cantero A,Reindl A, et al. 1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidicisoprenoid biosynthesis in plants [J]. J Biol Chem,2001,276(25):22901.
Pandit J,Danley D E,Schulte G K,et al. Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis [J]. J Biol Chem,2000,275(39):30610.
[14]
Shechter I. The road to squalene synthase[J]. Bio Chem Bioph Res Co,2002,292(5):1261.
[15]
Yang R Y, Feng L L,Yang X Q, et al. Quantitative transcript profiling reveals down-regulation of a sterol pathway relevant gene and overexpression of artemisinin biogenetic genes in transgenic Artemisia annua plants[J]. Planta Med,2008,74(12):1510.
[16]
Kim T D,Han J Y,Huh G H,et al. Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng[J]. Plant Cell Physiol,2011,52(1):125.
[17]
孙颖, 赵恒伟, 葛锋, 等. 三七中 SS 基因超表达载体的构建及其遗传转化[J]. 药学学报, 2013, 48(1):138.
[18]
Hayashi H,Hirota A,Hiraoka N,et al. Molecular cloning and characterization of two cDNAs for Glycyrrhiza glabra squalene synthase [J]. Biol Pharm Bull,1999,22(9):947.
[19]
Huang Z,Jiang K,Pi Y,et al. Molecular cloning and characterization of the yew gene encoding squalene synthase from Taxus cuspidata[J]. J Steroid Biochem,2007,40(5):625.
[20]
Zhao M W,Liang W Q,Zhang D B,et al. Cloning and characterization of squalene synthase (SQS) gene from Ganoderm alucidum[J]. J Microbiol Biotechn,2007,17(7):1106.
[21]
Olofsson L,Engstr?m A, Lundgren A, et al. Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L.[J]. BMC Plant Biol,2011,11(1):45.
[22]
Jennings S M, Tsay Y H, Fisch T M, et al. Molecular cloning and characterization of the yeast gene for squalenesynthetase[J]. Proc Natl Acad Sci USA, 1991, 88(14):6038.
[23]
Robinson G W, Tsay Y H, Kienzle B K, et al. Conservation between human and fungal squalenesynthetases:similarities in structure, function, and regulation[J]. Mol Cell Biol, 1993, 13(5):2706.
[24]
Uchida H, Yamashita H, Kajikawa M, et al. Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L[J]. Planta, 2009, 229(6):1243.
[25]
Hata S, Sanmiya K, Kouchi H, et al. cDNA cloning of squalene synthase genes from mono-and dicotyledonous plants, and expression of the gene in rice[J]. Plant Cell Physiol, 1997, 38(12):1409.
[26]
Devarenne T P, Shin D H, Back K, et al. Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor[J]. Arch Biochem Biophys, 1998, 349(2):205.
[27]
Busquets A, Keim V, Closa M, et al. Arabidopsis thaliana contains a single gene encoding squalene synthase[J]. Plant Mol Biol, 2008, 67(1/2):25.
[28]
Nguyen H, Neelakadan A K, Quach T N, et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis [J]. Plant Physiol Biochem,2013,73:23.
[29]
Kim T D, Han J Y, Huh G H, et al. Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng[J]. Plant Cell Physiol, 2011, 52(1):125.