OALib Journal期刊
分子内氧化偶联反应在合成复杂吲哚生物碱骨架中的应用有机化学
DOI: 10.6023/cjoc201301035
Keywords: 分子内氧化偶联 ,吲哚生物碱 ,全合成 ,多环螺吲哚啉 ,吲哚并吡咯环
Abstract:
通过含有吲哚底物的分子内氧化偶联反应,成功地构建了Communesin家族生物碱的螺吲哚啉季碳中心,从而完成了(-)-CommunesinsA,B和F的对映选择性合成.接下来我们发展了分子内氧化偶联/缩合串联反应策略,得到了天然产物(-)-Vincorine的核心四环骨架,然后再经过五步转化完成了Vincorine的全合成.从药物化学角度来看,分子内氧化偶联/缩合串联提供了一个快速方便地合成含有多环吲哚啉骨架的方法.采用相同的串联反应策略,我们分别从色胺衍生的β-酮酸酰胺和丙二酸二酰胺出发,一步构建了多环螺吲哚啉和多环吲哚啉并吡咯环骨架分子.
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