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化毒为药:三氧化二砷对急性早幼粒白血病治疗作用的发现

, PP. 700-707

Keywords: 白血病,砒霜,三氧化二砷,张亭栋

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Abstract:

在三氧化二砷(arsenictrioxide,ATO)被视为“对急性早幼粒白血病(APL)病人最为有效的单体”的情况下,令人惊讶的是:最重要的发现者鲜为人知,其原始论文迄今未被一篇英文研究论文所引用.该发现产生于20世纪70年代初期,当时大多数中国科学家和医生处于困难时期.始于乡村中医针对性含糊的复方,张亭栋与同事于20世纪70年代提出复方中单一的化学分子起作用、其最敏感对象为APL.张亭栋和同事20多年的工作扫除了“能否”和“如何”有效使用ATO的困惑.此后中国和西方的其他研究者跟随张亭栋等的先驱工作.张亭栋小组回顾性分析自己的资料证明APL确实为ATO最敏感的对象.张亭栋所在医院另一研究组将原本微量的氯化亚汞从配方中完全去除证明ATO单独可以治疗APL.1998年西方研究者发表重复和证明中国发现的论文导致ATO疗法被广泛接受.不过,ATO相关英文论文的西方或中国作者皆未引用张亭栋等在20世纪70年代的文章.本文集中介绍张亭栋等的早期文献,但也提示进一步研究和验证中国报道ATO对其他肿瘤的作用,认为中国刊物发表的一些发现可能对病人有相当价值,其他国家的医生可能得益于有最大病人群落的中国医生之临床经验.

References

[1]  Au W Y, Kumana C R, Lee H K K, et al. Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study. Blood, 2011, 118: 6535-6543
[2]  Bernard J, Weil M, Boiron M, et al. Acute promyelocytic leukemia: results of treatment by daunorubicin. Blood, 1973, 41: 489-496
[3]  Bernard J, Weil M, Jacquillat C I. Treatment of acute granulocytic leukemias. Ann Rev Med, 1974, 25: 39-50
[4]  Boiron M, Weil M, Jacquillat C, et al. (1969). Daunorubicin in the treatment of acute myelocytic leukaemia. Lancet, 1969, 293: 330-333
[5]  Breitman T R, Selonick S E, Collins S J. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA, 1980, 70: 2936-2940
[6]  Breitman T R, Collins S J, Keene B R. Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood, 1981, 57: 1000-1004
[7]  Castaigne S, Chomienne C, Daniel M T, et al. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood, 1990, 76: 1704-1709
[8]  朝阳人民医院儿科. 砷剂合并化疗治疗白血病的体会. 辽宁抗癌战讯(内部资料注意保存), 1972, 7: 23-24
[9]  Chen G Q, Zhu J, Shi X G, et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia. As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR α/PML proteins. Blood, 1996, 88: 1052-1061
[10]  Chen G Q, Shi X G, Tang W, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL), I: As2O3 exerts dose-dependent dual effects on APL cells. Blood, 1997, 89: 3345-3353
[11]  陈国强, 陈赛娟, 王振义, 等. 氧化砷注射液治疗早幼粒细胞性白血病的机制研究及展望. 中国中西医结合杂志, 1998, 18: 581-582
[12]  Chen S J, Zhou G B, Zhang X W, et al. From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood, 2011, 117: 6425-6437
[13]  Chen Z X, Xue Y Q, Zhang R, et al. A clinical and experimental study on all-trans retinoic acid treated acute promyelocytic leukemia patients. Blood, 1991, 78: 1413-1419
[14]  Chomienne C, Ballerini P, Balitrand N, et al. Retinoic acid therapy for promyelocytic leukemia. Lancet, 1989, 334: 746-747
[15]  Collins S J, Gallo R C, Gallagher R E. Continuous growth and differentiation of human myeloid leukemic cells in suspension culture. Nature, 1977, 270: 347-349
[16]  Daenen S, Vellenga E, van Dobbenbugh O A, et al. Retinoic acid as antileukemic therapy in a patient with acute promyelocytic leukemia and Aspergillus pneumonia. Blood, 1986, 67: 559-561
[17]  哈尔滨医科大学附属第一医院中医科(指导: 张亭栋. 执笔: 李元善, 胡晓晨. 参加人: 李明祥, 张鹏飞, 荣福祥, 孙洪德, 李会荣, 吴云霞, 检验科血研究室). 癌灵一号结合辨证施治治疗急性粒细胞型白血病73例临床小结. 黑龙江中医药, 1981, 4: 28-30
[18]  哈尔滨医科大学附属第一医院中医科, 哈尔滨医科大学附属第一医院检验科. 癌灵1号注射液与辨证论治对17例白血病的疗效观察. 哈医大学报, 1974, 2: 25-30
[19]  段秀绵, 辛晓敏, 王凤芹, 等. 癌灵Ⅰ号对急性早幼粒细胞性白血病(APL)患者白血病细胞抗癌活性的作用. 实用肿瘤学杂志, 1992, 2: 29-30
[20]  Ellison R R, Holland J F, Weil M, et al. Arabinosyl cytosine: a useful agent in the treatment of acute leukemia in adults. Blood, 1968, 32: 507-523
[21]  Estey E H. Newly diagnosed acute promyelocytic leukemia: arsenic moves front and center. J Clin Oncol, 2011, 29: 2743-2746
[22]  Flynn P, Miller W, Weisdorf D, et al. Retinoic acid treatment of acute promyelocytic leukemia: in vitro and in vivo observations. Blood, 1983, 62: 1211-1217
[23]  Fontana J A, Roger I S, Durham J P. The role of 13-cis retinoic acid in the remission induction of a patient with acute promyelocytic leukemia. Cancer, 1986, 57: 209-217
[24]  顾德謦. 中药“55”治疗白血病疗效的初步观察. 哈尔滨中医, 1964, 15: 24
[25]  关继仁. 白血病(49例临床分析). 黑龙江医学, 1958, 2: 22-34
[26]  Guo H X, Chen W, Liu L X, et al. Recent status of the effect of arsenic trioxide on colon cancer. Chin J Integr Trad West Med Dig, 2006, 14: 207-209
[27]  中医研究院西苑医院内科血液组. 白血病的中医治疗. 广东医学, 1974, 5: 31-37
[28]  Honma Y, Fujita Y, Kasukabe T, et al. Induction of differentiation of human acute non-lymphocytic leukemia cells in primary culture by inducers of differentiation of human myeloid leukemia cell line HL-60. Eur J Cancer Clin Oncol, 1983, 19: 251-261
[29]  胡晓梅, 刘峰, 麻柔, 等. 周霭祥运用青黄散治疗白血病的经验. 中医杂志, 2011, 52: 1187-1189
[30]  Huang M E, Ye Y C, Chen S R, et al. All-trans retinoic acid with or without low dose cytosine arabinoside in acute promyelocytic leukemia: report of 6 cases. Chin Med J, 1987, 100: 949-953
[31]  Huang M E, Ye Y C, Chen S R, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 1988, 72: 567-572
[32]  黄世林, 郭爱霞, 向阳, 等. 复方青黛片为主治疗急性早幼粒白血病的临床研究. 中华血液学杂志, 1995, 6: 26-28
[33]  Jolliffe D M A history of the use of arsenicals in man. J Royal Soc Med, 1993, 86: 287-289
[34]  Koeffler H P. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood, 1983, 62: 709-721
[35]  李元善, 张亭栋, 王兴榕, 等. 癌灵1号注射液对人肝癌细胞杀伤动力学研究. 肿瘤防治研究, 1988, 15: 1-3
[36]  Liu L X, Zhu A L, Chen W, et al. Effect of arsenic trioxide on hepatocellular carcinoma and its mechanistic studies. Chin J Surg, 2005, 43: 33-36
[37]  Mervis J. Cancer research: ancient remedy performs new tricks. Science, 1996, 273: 578
[38]  Nilsson B. Probable in vivo induction of differentiation by retinoic acid acid of promyelocytes in acute promyelocytic leukemia. British J Haematol, 1984, 57: 365-371
[39]  Niu C, Yan H, Yu T, et al. Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood, 1999, 94: 3315-3324
[40]  Olsson I L, Breitman T R. Induction of differentiation of the human histiocytic lymphoma cell line U-937 by retinoic acid and cyclic adenosine 3'': 5''-monophosphate-inducing agents. Cancer Res, 1982, 42: 3924-3927
[41]  Breitman T R. Induction of terminal differentiation of l-IL-60 and fresh leukemic cells by retinoic acid, p.257. In: Revoltella R F, ed. Expression of Differentiated Functions in Cancer Cells. New York: Raven, 1982
[42]  Powell B L, Moser B, Stock W, et al. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. Blood, 2010, 116: 3751-3757
[43]  荣福祥, 张亭栋. 急性粒细胞性白血病长期存活2例报告. 新医药学杂志, 1979, 6: 31-34
[44]  Rosenthal E. Chairman Mao''s cure for cancer. New York Times, May 6th, 2001
[45]  Sanz M A, Grimwade D, Tallman M S, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood, 2009, 113: 1875-1891
[46]  Sanz M A, Lo-Coco F. Modern approaches to treating acute promyelocytic leukemia. J Clin Oncol, 2011, 29: 495-503
[47]  Sears D A. History of the treatment of chronic myelocytic leukemia. Am J Med Sci, 1988, 296: 85-86
[48]  Shen Z X, Chen G Q, Ni J H, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL), II: clinical efficacy and pharmacokinetics in relapsed patients. Blood, 1997, 89: 3354-3360
[49]  Soignet S L, Maslak P, Wang Z G, et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med, 1998, 339: 1341-1348
[50]  孙鸿德, 马玲, 胡晓晨, 等. 癌灵1号结合中医辨证施治急性早幼粒白血病长期存活16例报告. 中医药信息, 1991, 6: 39-41
[51]  孙鸿德, 马玲, 胡晓晨, 等. 癌灵1号结合中医辨证治疗急性早幼粒白血病32例. 中国中西医结合杂志, 1992, 12: 170-171
[52]  Tallman M S, Andersen J W, Schiffer C A, et al. All-trans-retinoic acid in acute promyelocytic leukemia. N Engl J Med, 1997, 337: 1021-1028
[53]  Tallman M S, Altman J K. How I treat acute promyelocytic leukemia. Blood, 2009, 114: 51260-51235
[54]  Warrell Jr R P, Frankel S T, Miller Jr W H, et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med, 1991, 324: 1385-1393
[55]  徐敬肃, 段秀绵, 徐莹, 等. 癌灵1号治疗急性早又粒白血病20年一例. 中华血液杂志, 1997, 18: 476
[56]  张鹏, 王树叶, 胡龙虎, 等. “713”(As2O3)治疗早幼粒白血病117例临床观察与机制探讨. 哈尔滨医科大学学报, 1995, 29: 243
[57]  张鹏, 王树叶, 胡龙虎, 等. 三氧化二砷注射液治疗72例急性早幼粒细胞白血病. 中华血液学杂志, 1996, 17: 58-60
[58]  张鹏. 发现三氧化二砷的历史. http://blog.sciencenet.cn/blog-870683-663068.html, 2013
[59]  张亭栋. 谈谈中西医结合临床科研设计中的几个问题. 中西医结合杂志, 1982, 2: 180-181
[60]  张亭栋. 中医对白血病的认识和治疗. 中医杂志, 1983, 3: 71-74
[61]  张亭栋. 急性非淋巴细胞性白血病证治. 中西医结合杂志, 1985, 5: 713
[62]  张亭栋, 李元善. 癌灵1号治疗急性粒细胞白血病临床发现和实验研究. 中西医结合杂志, 1984, 4: 19-20
[63]  张亭栋, 张鹏飞, 王守仁, 等. “癌灵注射液”治疗6例白血病初步临床观察. 黑龙江医药, 1973, 3: 66-67
[64]  张亭栋, 荣福祥. 癌灵一号注射液与辩证论治治疗急性粒细胞型白血病. 黑龙江医药, 1979, 4: 7-11
[65]  Zhang T D, Chen G Q, Wang Z G, et al. Arsenic trioxide, a therapeutic agent for APL. Oncogene, 2001, 20: 7146-7153
[66]  周霭祥. 青黄散治疗白血病研究. 中国中西医结合杂志, 1998, 18: 582-583
[67]  Zhu J, Chen Z, Lallemand-Breitenbach V, et al. How acute promyelocytic leukaemia revived arsenic. Nat Rev Cancer, 2001, 2: 705-714

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