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Molecules  2015 

A Novel One-Pot Green Synthesis of Dispirooxindolo-pyrrolidines via 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides

DOI: 10.3390/molecules20010780, PP. 780-791

Keywords: 1,3-dipolar cycloaddition, azomethine ylide, dispiropyrrolidines, ionic liquids

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Abstract:

A facile synthesis of dispirooxindolopyrrolidines has been accomplished via a one-pot three component 1,3-dipolar cycloaddition reaction. The reaction of azomethine ylides generated in situ from L-phenylalanine and substituted isatins with a series of unusual ( E)-2-oxoindolino-3-ylidene acetophenone dipolarophiles in the ionic liquid 1-butyl-3-methylimidazolium bromide [bmim]BF 4, furnished the cycloadducts in good yields, with the regioisomers 5a– f being obtained with high selectivity. Furthermore, the recyclability of [bmim]BF 4, up to five times, was also investigated.

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