%0 Journal Article
%T A Novel One-Pot Green Synthesis of Dispirooxindolo-pyrrolidines via 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides
%A Abdulrahman I. Almansour
%A Natarajan Arumugam
%A Raju Suresh Kumar
%A Govindasami Periyasami
%A Hazem A. Ghabbour
%A Hoong-Kun Fun
%J Molecules
%P 780-791
%D 2015
%I MDPI AG
%R 10.3390/molecules20010780
%X A facile synthesis of dispirooxindolopyrrolidines has been accomplished via a one-pot three component 1,3-dipolar cycloaddition reaction. The reaction of azomethine ylides generated in situ from L-phenylalanine and substituted isatins with a series of unusual ( E)-2-oxoindolino-3-ylidene acetophenone dipolarophiles in the ionic liquid 1-butyl-3-methylimidazolium bromide [bmim]BF 4, furnished the cycloadducts in good yields, with the regioisomers 5a¨C f being obtained with high selectivity. Furthermore, the recyclability of [bmim]BF 4, up to five times, was also investigated.
%K 1
%K 3-dipolar cycloaddition
%K azomethine ylide
%K dispiropyrrolidines
%K ionic liquids
%U http://www.mdpi.com/1420-3049/20/1/780