Background. Chemical spills are on the rise and inhalation of toxic chemicals may induce chemical acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Although the pathophysiology of ALI/ARDS is well understood, the absence of specific antidotes has limited the effectiveness of therapeutic interventions.
References
[1]
Almlén A, Walther FJ, Waring AJ, Robertson B, Johansson J, Curstedt T. 2010. Synthetic surfactant based on analogues of SP-B and SP-C is superior to single-peptide surfactants in ventilated premature rabbits. Neonatology 98:91-99
[2]
Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. 1994. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. American Journal of Respiratory and Critical Care Medicine 149:818-824
[3]
Brackenbury AM, Puligandla PS, McCaig LA, Nikore V, Yao LJ, Veldhuizen RA, Lewis JF. 2001. Evaluation of exogenous surfactant in HCL-induced lung injury. American Journal of Respiratory and Critical Care Medicine 163:1135-1142
[4]
Brower RG, Fessler HE. 2011. Another “negative” trial of surfactant. Time to bury this idea? American Journal of Respiratory and Critical Care Medicine 183:966-968
[5]
Chiumello D, Pristine G, Slutsky AS. 1999. Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine 160:109-116
[6]
Curstedt T, Calkovska A, Johansson J. 2013. New generation synthetic surfactants. Neonatology 103:327-330
[7]
Curstedt T, Johansson J, Persson P, Eklund A, Robertson B, Lowenadler B, Jornvall H. 1990. Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. Proceedings of the National Academy of Sciences of the United States of America 87:2985-2989
[8]
Czaja AS. 2007. A critical appraisal of a randomized controlled trial: Willson et al.: effect of exogenous surfactant (calfactant) in pediatric acute lung injury (JAMA 2005, 293: 470-476) Pediatric Critical Care Medicine 8:50-53
[9]
Dushianthan A, Cusack R, Goss V, Postle AD, Grocott MP. 2012. Clinical review: exogenous surfactant therapy for acute lung injury/acute respiratory distress syndrome—where do we go from here? Critical Care 16:238
[10]
Goerke J. 1998. Pulmonary surfactant: functions and molecular composition. Biochimica et Biophysica ACTA/General Subjects 1408:79-89
[11]
Goormaghtigh E, Cabiaux V, Ruysschaert J-M. 1990. Secondary structure and dosage of soluble and membrane proteins by attenuated total reflection Fourier-transform infrared spectroscopy on hydrated films. European Journal of Biochemistry 193:409-420
[12]
Gorguner M, Aslan S, Inandi T, Cakir Z. 2004. Reactive airways dysfunction syndrome in housewives due to a bleach-hydrochloric acid mixture. Inhalation Toxicology 16:87-91
[13]
Ito Y, Goffin J, Veldhuizen R, Joseph M, Bjarneson D, McCaig L, Yao LJ, Marcou J, Lewis J. 1996. Timing of exogenous surfactant administration in a rabbit model of acute lung injury. Journal of Applied Physiology 80:1357-1364
[14]
Johansson J. 1998. Structure and properties of surfactant protein C. Biochimica et Biophysica Acta (BBA) — Molecular Basis of Disease 1408:161-172
[15]
Johansson J, Curstedt T, Jornvall H. 1991. Surfactant protein B: disulfide bridges, structural properties, and kringle similarities. Biochemistry 30:6917-6921
[16]
Johansson J, Nilsson G, Stromberg R, Robertson B, Jornvall H, Curstedt T. 1995. Secondary structure and biophysical activity of synthetic analogues of the pulmonary surfactant polypeptide SP-C. Biochemical Journal 307:535-541
[17]
Johansson J, Some M, Linderholm BM, Almlén A, Curstedt T, Robertson B. 2003. A synthetic surfactant based on a poly-Leu SP-C analog and phospholipids: effects on tidal volumes and lung gas volumes in ventilated immature newborn rabbits. Journal of Applied Physiology 95:2055-2063
[18]
Lamm WJ, Albert RK. 1990. Surfactant replacement improves lung recoil in rabbit lungs after acid aspiration. American Review of Respiratory Disease 142:1279-1283
Matthay MA, Ware LB, Zimmerman GA. 2012. The acute respiratory distress syndrome. Journal of Clinical Investigation 122:2731-2740
[21]
Maynard RM, Tetley TD. 2004. Bioterrorism: the lung under attack. Thorax 59:188-189
[22]
Notter RH. 2000. Lung surfactants: basic science and clinical applications. New York: Marcel Dekker.
[23]
Pastrana B, Maulone AJ, Mendelsohn R. 1991. Fourier transform infrared studies of secondary structure and orientation of pulmonary surfactant SP-C and its effect on the dynamic surface properties of phospholipids. Biochemistry 30:10058-10064
[24]
Polin RA, Carlo WA, Committee on Fetus and Newborn. 2014. Surfactant replacement therapy for preterm and term neonates with respiratory distress. Pediatrics 133:156-163
[25]
Rosenthal C, Caronia C, Quinn C, Lugo N, Sagy M. 1998. A comparison among animal models of acute lung injury. Critical Care Medicine 26:912-916
[26]
Seurynck-Servoss SL, Brown NJ, Dohm MT, Wu CW, Barron AE. 2007. Lipid composition greatly affects the in vitro surface activity of lung surfactant protein mimics. Colloids and Surfaces B: Biointerfaces 57:37-55
[27]
Spragg RG, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Hfner D, Taut FJ, Seeger W. 2004. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. New England Journal of Medicine 351:884-892
[28]
Spragg RG, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Gunther A. 2011. Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. American Journal of Respiratory and Critical Care Medicine 183:1055-1061
[29]
Tanaka Y, Takei T, Aiba T, Masuda K, Kiuchi A, Fujiwara T. 1986. Development of synthetic lung surfactants. Journal of Lipid Research 27:475-485
[30]
Vandenbussche G, Clercx A, Curstedt T, Johansson J, Jornvall H, Ruysschaert JM. 1992. Structure and orientation of the surfactant-associated protein C in a lipid bilayer. European Journal of Biochemistry 203:201-209
[31]
Walther FJ, Gordon LM, Zasadzinski JA, Sherman MA, Waring AJ. 2000. Surfactant protein B and C analogues. Molecular Genetics and Metabolism 71:342-351
[32]
Walther FJ, Hernández-Juviel J, Bruni R, Waring AJ. 1998. Protein composition of synthetic surfactant affects gas exchange in surfactant-deficient rats. Pediatric Research 43:666-673
[33]
Walther FJ, Hernandez-Juviel J, Gordon LM, Waring AJ, Stenger P, Zasadzinski JA. 2005. Comparison of three lipid formulations for synthetic surfactant with a surfactant protein B analog. Experimental Lung Research 31:563-579
[34]
Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Wang Z, Jung CL, Ruchala P, Clark AP, Smith WM, Sharma S, Notter RH. 2010. Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. PLoS ONE 5:e8672
[35]
Walther FJ, Waring AJ, Sherman MA, Zasadzinski JA, Gordon LM. 2007. Hydrophobic surfactant proteins and their analogues. Neonatology 91:303-310
[36]
Wang Z, Gurel O, Baatz JE, Notter RH. 1996. Acylation of pulmonary surfactant protein-C is required for its optimal surface active interactions with phospholipids. The Journal of Biological Chemistry 271:19104-19109
[37]
Waring AJ, Walther FJ, Gordon LM, Hernandez-Juviel JM, Hong T, Sherman MA, Alonso C, Alig T, Braun A, Bacon D, Zasadzinski JA. 2005. The role of charged amphipathic helices in the structure and function of surfactant protein B. Journal of Peptide Research 66:364-374
[38]
White CW, Martin JG. 2010. Chlorine gas inhalation. Human clinical evidence of toxicity and experience in animal models. Proceedings of the American Thoracic Society 7:257-263
[39]
Whitsett JA, Weaver TE. 2002. Hydrophobic surfactant proteins in lung function and disease. New England Journal of Medicine 347:2141-2148
[40]
Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, Jacobs BR, Jefferson LS, Conaway MR, Egan EA, Pediatric Acute Lung Injury and Sepsis Investigators. 2005. Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA 293:470-476
[41]
Zimmermann AM, Roberts KD, Lampland AL, Meyers PA, Worwa CT, Plumm B, Pacheco MC, Wolfson MR, Mammel MC. 2010. Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury. Pediatric Pulmonology 45:782-788
