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益气类中药对博来霉素致肺纤维化大鼠模型气道重塑的影响
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Abstract:
目的：观察博莱霉素(BLM)所致肺纤维化模型大鼠肺组织病理形态和肺组织中转化生长因子(TGF-β1)的表达水平，探讨益气类中药对肺纤维化的作用及其机制。方法：32只健康雄性SD大鼠随机分为空白组、模型组、益气组、泼尼松组，采用气管内滴加博莱霉素的方法制作肺纤维化模型，并应用相应的药物灌胃干预，各组大鼠分别于第28 d处死，肺组织切片经HE染色后观察病理形态，ELISA法测定大鼠肺组织中TGF-β1的表达水平。结果：与空白组比较，其余各组大鼠肺组织中TGF-β1表达明显增强(P < 0.01)；两治疗组肺纤维化程度较模型组明显减轻(P < 0.01)，TGF-β1表达也明显低于模型组(P < 0.01)；益气组肺纤维化程度较泼尼松组轻(P < 0.05)，TGF-β1表达也明显低于泼尼松组(P < 0.01)。结论：益气类中药能够抑制
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