%0 Journal Article
%T 益气类中药对博来霉素致肺纤维化大鼠模型气道重塑的影响<br>Effects of Qi Invigorating Herbs on the Airway Remodeling of Bleomycin Induced Pulmonary Fibrosis in Rats Model
%A 郑建
%A 张伟
%A 朱雪
%A 王丽芹
%A 杨景青
%A 李莹莹
%A 郭俊美
%J Traditional Chinese Medicine
%P 10-14
%@ 2166-6059
%D 2014
%I Hans Publishing
%R 10.12677/TCM.2014.31004
%X <b><span style=\"font-family:宋体;font-size:10pt;\">目的：</span></b><span style=\"font-family:宋体;font-size:10pt;\">观察博莱霉素</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">BLM</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">所致肺纤维化模型大鼠肺组织病理形态和肺组织中转化生长因子</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">TGF-β1</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">的表达水平，探讨益气类中药对肺纤维化的作用及其机制。<b>方法：</b></span><span style=\"font-size:10pt;\">32</span><span style=\"font-family:宋体;font-size:10pt;\">只健康雄性</span><span style=\"font-size:10pt;\">SD</span><span style=\"font-family:宋体;font-size:10pt;\">大鼠随机分为空白组、模型组、益气组、泼尼松组，采用气管内滴加博莱霉素的方法制作肺纤维化模型，并应用相应的药物灌胃干预，各组大鼠分别于第</span><span style=\"font-size:10pt;\">28 d</span><span style=\"font-family:宋体;font-size:10pt;\">处死，肺组织切片经</span><span style=\"font-size:10pt;\">HE</span><span style=\"font-family:宋体;font-size:10pt;\">染色后观察病理形态，</span><span style=\"font-size:10pt;\">ELISA</span><span style=\"font-family:宋体;font-size:10pt;\">法测定大鼠肺组织中</span><span style=\"font-size:10pt;\">TGF-β1</span><span style=\"font-family:宋体;font-size:10pt;\">的表达水平。<b>结果：</b>与空白组比较，其余各组大鼠肺组织中</span><span style=\"font-size:10pt;\">TGF-β1</span><span style=\"font-family:宋体;font-size:10pt;\">表达明显增强</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">P &lt; 0.01</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">；两治疗组肺纤维化程度较模型组明显减轻</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">P &lt; 0.01</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">，</span><span style=\"font-size:10pt;\">TGF-β1</span><span style=\"font-family:宋体;font-size:10pt;\">表达也明显低于模型组</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">P &lt; 0.01</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">；益气组肺纤维化程度较泼尼松组轻</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">P &lt; 0.05</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">，</span><span style=\"font-size:10pt;\">TGF-β1</span><span style=\"font-family:宋体;font-size:10pt;\">表达也明显低于泼尼松组</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">P &lt; 0.01</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">。<b>结论：</b>益气类中药能够抑制</span><span
%K 肺纤维化；益气类中药；TGF-β1；转化生长因子；气道重塑<br>Pulmonary Fibrosis
%K Qi Invigorating Herbs
%K TGF-β1
%K Transforming Growth Factor
%K Airway Remodeling
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=13129