全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用：99美元
投递稿件

查看量下载量

相关文章

更多...

尿酸和血清胱抑素C对高血压肾损害早期诊断的预测价值
Prediction of Renal Damage Complicated by Hypertension With Uric Acid and Serum Cystatin C as Early Marker

DOI: 10.12677/ACM.2013.34007, PP. 25-28

Keywords: 尿酸；胱抑素C；高血压；早期肾损害
Uric Acid, Cystatin C, Hypertension, Early Impairment of Renal Function

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的: 探讨血尿酸和血清胱抑素C对高血压肾损害的早期诊断价值。方法: 前瞻性纳入我院收治的原发性高血压患者151例。根据是否并发肾损害，将患者分为单纯高血压组(I组)和高血压肾损害组(Ⅱ组)，采用全自动生化分析仪同时测定血清尿酸、肌酐和尿素氮，免疫透射比浊法测定血清胱抑素C含量，并与健康体检者(对照组)相关指标作对比研究，并进行相关分析，评价血尿酸和血清胱抑素C对高血压肾损害早期诊断的价值。结果：I组、Ⅱ组血尿酸和血清胱抑素C的阳性率明显高于对照组(P < 0.01)。同组患者血尿酸和血清胱抑素C的阳性率明显高于其血尿素和血肌酐阳性率(P < 0.01)。此外，高血压患者血尿酸和血清胱抑素C的升高早于血尿素和血肌酐。结论: 血尿酸和血清胱抑素C是反映高血压早期肾功能损害的敏感指标，其敏感度高于血尿素和血肌酐，在诊断高血压早期肾损害方面有重要的临床价值。
>Abstract:

References

[1]  Bagshaw, S.W. and Gibney, R.T. (2008) Conventional markers of kidney function. Crit Care Med, 36, S152-S158.
[2]  陆再英, 钟南山, 主编 (2008) 内科学. 北京人民卫生出版社, 北京, 51-262.
[3]  Mule, G., Cottone, S., Nardi, E., et a1. (2006) Metabolic syndrome in subjects with essential hypertension: Relationships with subclinical cardiovascular and renal damage. Minerva Car- dioangiologica, 54, 173-194．
[4]  Talaat, K.M. and EI-Sheikh, A.R. (2007) The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease. American Journal of Nephrology, 27, 435-440．
[5]  Convento, M.S., Pesson, E., Dalboni, M.A., et al. (2011) pro- inflammatory and oxidative effect of noncrystalline uric acid in human mesangial cells: Contribution to hyperuricemic glomerular damage. Urological Research, 39, 21-27.
[6]  Qian, Q., Kassem, K.M., Beierwaltes, W.H., et al. (2009) PGE2 causes mesangial cell hypertrophy and decreases expression of cyclin D3. Nephron Physiology, 113, 7-14.
[7]  Luc, G., Bard, J.M. and Lesueur, C. (2006) Plasma cystatin-C and development of Coro-nary heart disease: The PRIME Study. Atherosclerosis, 18, 375-380.
[8]  Bokenkamp, A., Herget-Rosenthal, S., Bokenkamp, R. and Cystatin, C. (2006) kidney function and cardiovascular rdisease. Pediatric Nephrology, 21, 1223-1230.
[9]  Madero, M., Sarnak, M.J. and Stevens, L.A. (2006) Serum cystatin C as a marker of glomerular filtrationrate. Current Opinion in Nephrology and Hypertension, 15, 610-616.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133