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Arterial pressure variations as parameters of brain perfusion in response to central blood volume depletion and repletionKeywords: arterial pulse pressure, arterial systolic pressure, cerebrovascular circulation, fluid therapies, body fluids, head-up tilt, spontaneous breathing Abstract: Rationale: A critical reduction in central blood volume (CBV) is often characterized by hemodynamic instability. Restoration of a volume deficit may be established by goal-directed fluid therapy guided by respiration-related variation in systolic- and pulse pressure (SPV and PPV). Stroke volume index (SVI) serves as a surrogate end-point of a fluid challenge but tissue perfusion itself has not been addressed.
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