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Therapeutic Implications of Immunogenic Cell Death in Human Cancer

DOI: 10.3389/fimmu.2013.00503

Keywords: dendritic cells, T cells, chemotherapy, immunogenic cell death, tumor antigens

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Abstract:

Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.

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