%0 Journal Article
%T Therapeutic Implications of Immunogenic Cell Death in Human Cancer
%A Fabio Palombo
%A Chiara Focaccetti
%A Vincenzo Barnaba
%J Frontiers in Immunology
%D 2014
%I Frontiers Media
%R 10.3389/fimmu.2013.00503
%X Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.
%K dendritic cells
%K T cells
%K chemotherapy
%K immunogenic cell death
%K tumor antigens
%U http://www.frontiersin.org/Journal/10.3389/fimmu.2013.00503/abstract