Chronic alcohol use is a common problem globally among the HIV-infected patients on ARV treatment regimens, leading to severe liver damage and increase in serum enzymes. The study
determined effect of chronic alcohol intake on serum enzymes (alanine
aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyl transferase (GGT)) in HIV-infected patients on d4T/3TC/NVP treatment regimen in Uganda
using the WHO alcohol use disorders’ identification test (AUDIT) tool and chronic alcohol use biomarkers
(ALT, AST, GGT, AST/ALT ≥2.0 and mean
corpuscular volume (MCV)). A case control study
using repeated measure design with serial measurements model was used. Alcohol
use biomarkers were used to standardize the gender differences in alcohol use.
A total of 41 patients (21 alcohol group and 20 control group) were followed up
for 9 months with blood sampling done at 3 month intervals. The serum enzymes’ levels were determined by using the Cobas Intergra 400 Plus
analyzer system. The mean GGT levels were higher in chronic alcohol use group
as compared to control group in both groups. The levels were
above reference ranges during 6 month and three times higher during 9-month follow-up period for both chronic alcohol
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