%0 Journal Article
%T Chronic Alcohol Consumption Affects Serum Enzymes Levels in the HIV-Infected Patients on Stavudine (d4T)/Lamivudine (3TC)/Nevirapine (NVP) Treatment Regimen
%A Godfrey S. Bbosa
%A David B. Kyegombe
%A William W. Anokbonggo
%A Aloysius Lubega
%A Apollo Mugisha
%A Jasper Ogwal-Okeng
%J Pharmacology & Pharmacy
%P 181-194
%@ 2157-9431
%D 2014
%I Scientific Research Publishing
%R 10.4236/pp.2014.52025
%X <p class=\"MsoNormal\">
	<span style=\"font-family:Verdana;\" lang=\"EN-US\">Chronic</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> alcohol use is a common problem globally </span><span style=\"font-family:Verdana;\" lang=\"EN-US\">among the</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> HIV-infected patients on ARV treatment regimens</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">,</span><span lang=\"EN-US\"><span style=\"font-family:Verdana;\"> leading to severe liver damage and increase in serum enzymes. The study
determined effect of chronic alcohol intake on serum enzymes (alanine
aminotransferase (ALT), aspartate aminotransferase (AST) and </span><i><span style=\"font-family:Verdana;\">¦Ã</span></i><span style=\"font-family:Verdana;\">-glutamyl transferase (GGT)</span></span><span style=\"font-family:Verdana;\" lang=\"EN-US\">)</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> in HIV-infected patients on d4T/3TC/NVP treatment regimen in Uganda
using the WHO alcohol use disorders</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">¡¯</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> identification test (AUDIT) tool and chronic alcohol use biomarkers
(ALT, AST, GGT, AST/ALT ¡Ý</span><span lang=\"EN-US\"> </span><span style=\"font-family:Verdana;\" lang=\"EN-US\">2.0 and mean
corpuscular volume (MCV)).</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> A case control study
using repeated measure design with serial measurements model was used. Alcohol
use biomarkers were used to standardize the gender differences in alcohol use.
A total of 41 patients (21 alcohol group and 20 control group) were followed up
for 9 months with blood sampling done at 3 month intervals. The serum enzyme</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">s¡¯ level</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">s were determined</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> by </span><span style=\"font-family:Verdana;\" lang=\"EN-US\">using the Cobas Intergra 400 Plus
analyzer system. The mean GGT levels were higher in chronic alcohol use group
as compared to control group in both groups</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">.</span><span style=\"font-family:Verdana;\" lang=\"EN-US\"> The levels were
above reference ranges during 6 month and three times higher during 9</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">-</span><span style=\"font-family:Verdana;\" lang=\"EN-US\">month follow-up period for both chronic alcohol</span><span lang=\"EN-US\">
%K Chronic Ethanol Use
%K Serum Enzymes
%K HIV-Infected Patients
%K Antiretroviral (ARVs) Drugs
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=42995