10-valent Protein D Conjugated Pneumococcal Vaccine (PHID-CV,Synflorix,GSK)

S.pneumoniae is the most important pathogen causing invasive disease such as meningitis and sepsis. Pneumococcal conjugate vaccines are vaccines designed to protect children from invasive diseases. Glaxo Smith Kline’s novel 10-valent pneumococcal conjugate vaccine (PH D-CV) includes serotypes 1.5 and 7F which are not in the 7-valent vaccine (Prevenar). Nontypeable H. influenzae (NTH ) is one of the two major pathogens that cause acute bacterial otitis media. PH D-CV has a new carrier, protein D, derived from NTH that potentially offers protection against NTH infection by virtue of the protein D carrier protein. This carrier also minimises the risk of interference with co-administered vaccines.Various studies demonstrated the immunogenicity (by EL SA and OPA), safety and tolerability of PH D-CV.