LEAVES EXTRACT OF MURRAYA KOENIGII LINN FOR ANTIINFLAMMATORY AND ANALGESIC ACTIVITY IN ANIMAL MODELS

This work has been done for the investigation of the anti-inflammatory andanalgesic activity of methanol extract of dried leaves of Murraya koenigii Linn by oraladministration at dose of 100, 200 and 400 mg/kg body weight, to healthy animals.Extract was studied for its anti-inflammatory activity by using carrageenan-induced hindpaw edema in albino rats and the mean increase in paw volume and % inhibition in pawvolume were measured plethysmometrically at different time intervals after carrageenan(1% w/v) injection. Extract was also evaluated for analgesic activity using Eddy’s hotplate method and formalin induced paw licking method in albino rats. The methanolextract showed significant (P < 0.001) reduction in the carrageenan-induced paw edemaand analgesic activity evidenced by increase in the reaction time by eddy’s hot platemethod and percentage increase in pain in formalin test. The methanol extract showedanti-inflammatory and analgesic effect in dose dependent manner when compared withthe control and standard drug, diclofenac sodium (10mg/kg, p.o). These inhibitions werestatistically significant (P < 0.05). Thus our investigation suggests a potential benefit ofMurraya koenigii in treating conditions associated with inflammatory pain.