%0 Journal Article
%T LEAVES EXTRACT OF MURRAYA KOENIGII LINN FOR ANTIINFLAMMATORY AND ANALGESIC ACTIVITY IN ANIMAL MODELS
%A Shailly Gupta
%A Mathew George
%A Manmohan Singhal
%A Ganesh N. Sharma
%J Journal of Advanced Pharmaceutical Technology & Research
%D 2010
%I Medknow Publications
%X This work has been done for the investigation of the anti-inflammatory andanalgesic activity of methanol extract of dried leaves of Murraya koenigii Linn by oraladministration at dose of 100, 200 and 400 mg/kg body weight, to healthy animals.Extract was studied for its anti-inflammatory activity by using carrageenan-induced hindpaw edema in albino rats and the mean increase in paw volume and % inhibition in pawvolume were measured plethysmometrically at different time intervals after carrageenan(1% w/v) injection. Extract was also evaluated for analgesic activity using Eddy¡¯s hotplate method and formalin induced paw licking method in albino rats. The methanolextract showed significant (P < 0.001) reduction in the carrageenan-induced paw edemaand analgesic activity evidenced by increase in the reaction time by eddy¡¯s hot platemethod and percentage increase in pain in formalin test. The methanol extract showedanti-inflammatory and analgesic effect in dose dependent manner when compared withthe control and standard drug, diclofenac sodium (10mg/kg, p.o). These inhibitions werestatistically significant (P < 0.05). Thus our investigation suggests a potential benefit ofMurraya koenigii in treating conditions associated with inflammatory pain.
%K Murraya koenigii
%K Analgesic
%K anti-inflammatory
%K paw licking
%U http://122.168.195.169/Online%20Admission/CourseInstr.aspx?STS=4&MID=63&Title=Leaves%20extract%20of%20Murraya%20koenigii%20Linn%20for%20anti-inflammatory%20and%20analgesic%20activity%20in%20animal%20models