SYNTHESIS, DOCKING AND BIOLOGICAL STUDIES OF THE LINEAR TETRAPEPTIDE PWPV

Linear Tetrapeptides L-PWPV (Pro-Trp-Pro-Val) was designed and synthesized by solution phase peptide synthesis based on dock score. The molecular docking studies of the designed tetrapeptide L-PWPV was carried out using Molegro Virtual Docker software for tumor cancer protein(1OLG). The linear tetrapeptide was synthesized by coupling protected amino acids (dipeptides) using EDC (ethyl-3-(N,N-dimethylamino)propyl carbodiimide) as coupling reagent. The compounds were analyzed by FTIR, 1H NMR and MASS data and subjected to antioxidant activity using 1,1-dipheny-2-picryl-hydrazil (DPPH) method and insecticidal activity using Morita et al method.