%0 Journal Article
%T SYNTHESIS, DOCKING AND BIOLOGICAL STUDIES OF THE LINEAR TETRAPEPTIDE PWPV
%A M. Himaja
%A Sanjay S
%A Poppy Das
%A Munirajasekhar D
%J International Research Journal of Pharmacy
%D 2012
%I International Research Journal of Pharmacy
%X Linear Tetrapeptides L-PWPV (Pro-Trp-Pro-Val) was designed and synthesized by solution phase peptide synthesis based on dock score. The molecular docking studies of the designed tetrapeptide L-PWPV was carried out using Molegro Virtual Docker software for tumor cancer protein(1OLG). The linear tetrapeptide was synthesized by coupling protected amino acids (dipeptides) using EDC (ethyl-3-(N,N-dimethylamino)propyl carbodiimide) as coupling reagent. The compounds were analyzed by FTIR, 1H NMR and MASS data and subjected to antioxidant activity using 1,1-dipheny-2-picryl-hydrazil (DPPH) method and insecticidal activity using Morita et al method.
%K Tetrapeptide
%K Solution phase peptide synthesis
%K Molegro Virtual Docker software
%K L-PWPV
%K DPPH
%K Antioxidant and Insecticidal activities.
%U http://www.irjponline.com/admin/php/uploads/1201_pdf.pdf