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Trials  2011 

Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial

DOI: 10.1186/1745-6215-12-46

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Abstract:

This randomized, single-blind clinical trial will be performed at two health centers and will include two periodontal treatment strategies. After medical/periodontal screening, a baseline endothelium-dependent brachial artery flow-mediated dilatation (FMD) and other systemic surrogate markers will be obtained from all recruited subjects. Patients then will be randomized to receive either supragingival/subgingival plaque cleaning and calculus removal plus chlorhexidine (treatment group) or supragingival plaque removal only (control group). A second and third FMD will be obtained after 24 hours and 12 weeks in both treatment arms. Each group will consist of 49 patients (n = 98) and all patients will be followed-up for secondary outcomes and will be monitored through a coordinating center. The primary outcomes are FMD differences baseline, 24 hours and 3 months after treatment. The secondary outcomes are differences in C-reactive protein (hs-CRP), glucose serum levels, blood lipid profile, and HOMA index.This RCT is expected to provide more evidence on the effects of different periodontal treatment modalities on FMD values, as well as to correlate such findings with different surrogate markers of systemic inflammation with cardiovascular effects.ClinicalTrials.gov Identifier: NCT00681564.Cardiovascular disease continues to be the main cause of morbidity and mortality worldwide. Despite the existence of novel therapeutic approaches designed for the prevention and treatment of atherosclerosis, the number of deaths associated to cardiovascular events remains constant in most countries[1]. For instance, in Colombia, one out of five deaths can be attributed to ischemic cardiovascular disease[2]. During the last decade it has been widely accepted that inflammation plays a key role in the development of atherosclerosis. Multiple epidemiological studies have confirmed the association between high levels of acute phase reactants such as C-reactive protein (CRP), fibrinogen, Ser

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