MULTICOMPONENT SOLVENT FREE SYNTHESIS OF 3, 4-DIHYDROPYRIMIDINE-2-[1H]-ONE AND 3, 4-DIHYDROPYRIMIDINE-2-[1H]-THIONE

A one pot, multicomponent condensation of an aldehyde, ethylacetoacetate, and urea/thiourea for the synthesis of 3,4-dihydropyrimidine-2-[1H]-thione/one (DHPMs) under solvent free conditions using CuSO .5H O in high 4 2 yields is described. The present methodology offers several advantages such as high yields