VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS

The voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetry. A linear relationship was observed between the peak current and the concentration of olopatadine over the range 1.0 x10-8 M to 4.0 x10-7 M. The limits of detection and limits of quantitation were found to be 1.92ng/mL and 6.34ng/mL respectively. The proposed method was successfully applied for the determination of olopatadine in pharmaceutical formulations without interference from excipients.