%0 Journal Article
%T VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS
%A N.Y. Sreedhar et al
%J International Journal of Pharmaceutical Sciences and Research
%D 2012
%I Society of Pharmaceutical Sciences and Research
%X The voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetry. A linear relationship was observed between the peak current and the concentration of olopatadine over the range 1.0 x10-8 M to 4.0 x10-7 M. The limits of detection and limits of quantitation were found to be 1.92ng/mL and 6.34ng/mL respectively. The proposed method was successfully applied for the determination of olopatadine in pharmaceutical formulations without interference from excipients.
%K Olopatadine
%K Stripping voltammetry
%K Hanging mercury drop electrode (HMDE)
%K Bulk drug
%K Pharmaceutical formulations
%U http://ijpsr.com/V3I8/19%20Vol.%203,%20Issue%208,%20IJPSR,%20Aug%202012,%20RA-1406,%20Paper%2019.pdf