Bone Marrow Derived Mesenchymal Stem Cells –A Boon for the Treatment of Complications in Diabetes Mellitus

Mammal Bone marrow is an invaluable source of Mesenchymal stem cells. Bone Marrow derived Mesenchymal Stem Cells (BM-MSCs) are multipotent, self-renewing cells found in almost all postnatal organs / tissues and are used in the treatment of various disease conditions. Diabetes mellitus is a metabolic syndrome characterized by increased levels of blood glucose leading to various complications like Diabetic Foot, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic Cardiomyopathy and Diabetic Nephropathy. BM-MSCs are able to differentiate into many cell types, and to proliferate ex vivo. These attributes makes them a potential therapeutic tool for cell replacement therapy in diabetes and other diseases. The present review discusses the isolation and culturing of BM-MSCs along with their potential as new therapeutic agent in the treatment of Diabetes related complications and its limitations.