Electrochemical behavior and differential pulse voltametric determination of an antineoplastic drug bicalutamide and pharmaceuticals formulations using glassy carbon electrode

The redox characteristics of the drug Bicalutamide at a glassy-carbon electrode (GCE) wasinvestigated for the first time in aqueous media by differential-pulse voltammetry (DPV) and cyclic voltammetry(CV). In Britton–Robinson (BR) buffer of pH 2.0–10.0, an irreversible and diffusion-controlled reduction voltagramwere developed. The dependence of the CV response of the developed cathodic peak on the sweep rate () andon depolarizer concentration was typical electrode-coupled chemical reaction mechanism (EC) in which anirreversible reaction is interposed between the charges. In BR buffer of pH 6 - 7, a well defined cathodic peakwas developed and the plot of peak current height of the DPV against Bicalutamide concentration at this peakpotential was linear in the range 1×10 8– 2.6 ×10 5 M with lower limits of detection (LOD) and quantization (LOQ)of 8 x 10-8 M and 1 ×10 7 M, with good selectivity and sensitivity. A relative standard deviation (RSD) forBicalutamide at a concentration of 4.5×10 5 M was 2.48% (n=6). The proposed method was successfully appliedto Bicalutamide determination in pharmaceutical samples and results are very good correlations with previouslyreported methods.