%0 Journal Article
%T Electrochemical behavior and differential pulse voltametric determination of an antineoplastic drug bicalutamide and pharmaceuticals formulations using glassy carbon electrode
%A Raghu K.
%A Chandrasekar A.
%A Sankaran K.R.
%J International Journal of Chemical Research
%D 2010
%I Bioinfo Publications
%X The redox characteristics of the drug Bicalutamide at a glassy-carbon electrode (GCE) wasinvestigated for the first time in aqueous media by differential-pulse voltammetry (DPV) and cyclic voltammetry(CV). In Britton¨CRobinson (BR) buffer of pH 2.0¨C10.0, an irreversible and diffusion-controlled reduction voltagramwere developed. The dependence of the CV response of the developed cathodic peak on the sweep rate () andon depolarizer concentration was typical electrode-coupled chemical reaction mechanism (EC) in which anirreversible reaction is interposed between the charges. In BR buffer of pH 6 - 7, a well defined cathodic peakwas developed and the plot of peak current height of the DPV against Bicalutamide concentration at this peakpotential was linear in the range 1¡Á10 8¨C 2.6 ¡Á10 5 M with lower limits of detection (LOD) and quantization (LOQ)of 8 x 10-8 M and 1 ¡Á10 7 M, with good selectivity and sensitivity. A relative standard deviation (RSD) forBicalutamide at a concentration of 4.5¡Á10 5 M was 2.48% (n=6). The proposed method was successfully appliedto Bicalutamide determination in pharmaceutical samples and results are very good correlations with previouslyreported methods.
%K Bicalutamide
%K Glassy carbon Electrode
%K Britton Robinson Buffer
%K Cyclic Voltammetry and Differential Pulse Voltammetry
%U http://www.bioinfo.in/uploadfiles/12796048442_2_2_IJCR.pdf