SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF VARIOUS N-SUBSTITUTED DERIVATIVES OF SULFONAMIDES

In the present study, a series of N-substituted sulfonamides have been synthesized. The reaction ofbenzene sulfonyl chloride (1) with O-anisidine (2) yielded N-(2-methoxyphenyl) benzenesulfonamide (3), which onbromination with bromine in the presence of acetic acid gave N-(4,5-dibromo-2-methoxyphenyl)benzenesulfonamide(6). The two products (3) and (6) further on treatment with alkyl halides/acyl halide in the presence of sodium hydrideyielded thirteen different N-substituted sulfonamides. The compounds were characterized by IR, EIMS and 1H-NMRand screened against acetyl cholinesterase, butyryl cholinesterase and lipoxygenase enzymes. The results revealedthat N-butyl-N-(4, 5-dibromo-2-methoxyphenyl)benzene sulfonamide (6d) and N-pentyl-N-(4,5-dibromo-2-methoxyphenyl)benzenesulfonamide (6e) exhibited good inhibitory potential against lipoxygenase.